920 ASSOCIATION OF OUTCOME WITH LEFT VENTRICULAR VOLUMES AND EJECTION FRACTION MEASURED WITH TWO-AND THREE-DIMENSIONAL ECHOCARDIOGRAPHY IN PATIENTS REFERRED FOR ROUTINE, CLINICALLY INDICATED STUDIES

Abstract Background LV volumes and LVEF measured by 3DE are more accurate repeatable than those calculated with 2DE. However, the added prognostic value of EF remains to be clarified. Objectives To analyze if left ventricular (LV) ejection fraction (EF) three-dimensional echocardiography (3DE) have an incremental over measurements obtained from two-dimensional (2DE) in patients referred a high-volume laboratory. Methods We using both 2DE 725 consecutive (67% men; 59±18 years) various clinical indications for routine study. Results were significantly larger, was lower when During follow-up (3.6±1.2 years), 111 (15.3%) all-cause deaths 248 (34.2%) cardiac hospitalizations occurred. Larger associated worse otcome independent age, creatinine, hemoglobin, atrial fibrillation, ischemic heart diseases). In stepwise Cox regression analyses, association death hospitalization data (CD: fibrillation disease) whose Harrel's C-index (HC) 0.775, augmented parameters. The CD not affected end-diastolic volume (EDV) either or 3DE. Conversely, it incremented (HC= 0.84, p<.001) 0.814, p<0.001). cumulative endpoint 0.64, p=0.002) augments EDV 0.786, p<0.001), end-systolic 0.801, p<0.001) correspondent parameters HC= 0.796, allp<0.001) addition, partition values mild, moderate severe reduction showed higher discriminative power (Log-Rank: χ2=98.3 vs. χ2=77.1; Finally, dilation defined according threshold discriminatory reference (3DE LVEDV: χ2=15.9, p<0.001 χ2=10.8, p=0.001; LVESV: χ2=24.4, χ2=17.4, p=0.001). Conclusions ESV stronger outcome had 2D LVEF. Moreover, corresponding reported current guidelines.